Severe sepsis is caused by a severe infection of some type, and it is the underlying infection process and the fact that one or more internal organs are not functioning properly as a result of the infection and the body’s response to it. A body wide inflammatory response and organ dysfunction or failure can lead to septic shock if not treated immediately. Many people die every single year as a result of severe sepsis. Severe sepsis may also be diagnosed when a severe infection causes tissue hypoperfusion as well. If sepsis is not treated immediately or the treatment is not effective this can lead to severe sepsis, and the kidneys, heart, and other internal organs may fail. Eventually septic shock can set in, and this complicates treatment even further. Even after the cause of the infection is eliminated the sepsis process can continue. The organ dysfunction that occurs during severe sepsis can cause permanent organ damage or even complete organ failure and death.